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Postherpetic neuralgia (PHN) is a debilitating condition resulting from herpes zoster infection, characterized by persistent pain that significantly impacts quality of life. This study aimed to investigate the white matter […]
Learn More >Virtual library docking can reveal unexpected chemotypes that complement the structures of biological targets. Seeking agonists for the cannabinoid-1 receptor (CB1R), we dock 74 million tangible molecules and prioritize 46 […]
Learn More >Migraine chronification very frequently exposes patients to the inevitable risk of excessive symptomatic intake that, in turn, prompts development of medication overuse headache (MOH). The latter further compromises headache severity […]
Learn More >Itch refers to an aversive sensation that generates a desire to scratch. The basolateral amygdala (BLA) activity is crucial in driving motivation, sensation, and emotional responses. Excitatory projections from the […]
Learn More >Comorbidities as risk factors for migraine onset: A systematic review and three-level meta-analysis.
Migraine is a debilitating neurological disease with a multifaceted pathophysiology. Pre-existing comorbidities may influence the risk of developing migraine. This review and meta-analysis aim to present a comprehensive overview of […]
Learn More >Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS). Demyelination in the CNS provokes hyperalgesia, negative emotions, and/or cognitive impairment. Cuprizone (CPZ)-induced demyelination is a major […]
Learn More >Migraine is a common condition that can cause intense headaches, often on one side of the head, along with symptoms like nausea and sensitivity to light and sound. These headaches […]
Learn More >This chapter will review the basic pharmacology of the canonical cannabinoid receptors. The endocannabinoid system is a complex signalling network involved in a wide range of physiological processes, including pain […]
Learn More >Spiking neural networks (SNNs) present the potential for ultra-low-power computation, especially when implemented on dedicated neuromorphic hardware. However, a significant challenge is the efficient conversion of continuous real-world data into […]
Learn More >Virtual reality (VR) is a promising intervention for both experimentally induced and clinical pain, but the factors contributing to the efficacy of VR remain relatively unclear, partially because selecting adequate […]
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