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Large-Scale Plasma Proteomics to Profile Pathways and Prognosis of Chronic Pain.

While increasing peripheral mechanisms related to chronic pain, the plasma proteomics profile associated with it and its prognosis remains elusive. This study utilizes 2923 plasma proteins and chronic pain of […]

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Evaluation of cannabis-derived anti-inflammatory and analgesic treatment in animals and identification of cannabinoid-based effective inhibition of prostaglandin through computational studies.

Many medical conditions are accompanied by severe pain. Acute pain refers to the experience of pain that lasts for only a few hours, whereas chronic pain is the ongoing emergence […]

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Painful Mondays: Exploring Weekly Sleep Variations and Pain Perception in Healthy Women-An Experimental Study.

Acute experimental sleep deprivation induces pain hypersensitivity, particularly in females. While the impact of extreme sleep loss on pain perception has been largely studied, how subtle sleep fluctuations, for example, […]

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Shared diagnostic biomarkers and underlying mechanisms between endometriosis and recurrent implantation failure.

Endometriosis (EMs) is a common condition that causes dysmenorrhea, chronic pelvic pain, and infertility, affecting millions of women worldwide. Despite the use of assisted reproductive technology, EMs patients often experience […]

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Near-infrared spectroscopic study of blood flow changes in the dorsolateral prefrontal cortex during pain relief by odor stimulation.

Chronic pain is an unpleasant experience caused by sensory and emotional instability, sometimes independent of actual tissue damage. Pain relief can greatly impact psychologic, social, and economic well-being. Aromatherapy has […]

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The Pharmacology of Cannabinoids in Chronic Pain.

Our objective was to provide an overview of the currently available scientific and clinical data supporting the use of and -derived products for the treatment of chronic pain disorders. We […]

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Exploring vestibulocerebellum-vestibular nuclei-spinal trigeminal nucleus causals communication and TRPV2 ion channel in a mouse model of vestibular migraine.

Vestibular migraine (VM) is a disorder characterized by recurrent episodes of dizziness or vertigo and is often accompanied by headache. The mechanisms underlying vestibular dysfunction and pain in VM remain […]

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A cryptic pocket in CB1 drives peripheral and functional selectivity.

The current opioid overdose epidemic highlights the urgent need to develop safer and more effective treatments for chronic pain. Cannabinoid receptor type 1 (CB1) is a promising non-opioid target for […]

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“Doctor-Led, Patient-Centered”: A Mixed-Method Research Comparing Patients’ and Doctors’ Treatment Outcome Choices for Chronic Low Back Pain.

Chronic low back pain (CLBP) significantly impacts quality of life. Treatment outcomes are influenced by the perspectives and expectations of both patients and doctors, making it crucial to understand these […]

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Treatment modalities for patients with Persistent Spinal Pain Syndrome Type II: A systematic review and network meta-analysis.

Appropriate management of patients with Persistent Spinal Pain Syndrome Type 2 (PSPS-T2) remains challenging. The need for robust evidence for treatment modalities is urgently pressing. The aim of this systematic […]

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