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Infiltrated Macrophages Aggravate TMJOA Chronic Pain via Piezo2 in IB4-TG Neurons.

Recent research indicates that macrophages in ganglia are linked to chronic pain, with Piezo2 ion channels playing a key role in pain sensation. Our study aims to elucidate the interplay […]

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Motivation to exercise in patients with chronic low back pain.

Chronic low back pain (CLBP) is one of the most common musculoskeletal problems worldwide. Even though regular exercise is recommended as the primary conservative approach in treating this condition, significant […]

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The trigeminal nerve in diabetes mellitus: A brief narrative review.

This brief narrative review discusses the clinical manifestations, diagnosis, and management of trigeminal nerve-related conditions, such as neuropathy and neuralgia, in patients with diabetes mellitus (DM). Although these conditions are […]

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Substance Use and Pain Curriculum Innovation: Establishing a Student-Faculty Partnership for Curricular Change.

The opioid overdose crisis had progressed broadly in the United States, with an 21% increase from 2016 to 2017, and specifically in Massachusetts, with a peak rate of 1,374 deaths […]

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Headaches Correlated With Increased Suicide Risk, Study Finds.

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QuickStats: Percentage* of Adults Aged ≥18 Years with Chronic Pain in the Past 3 Months, by Sex and Urbanization Level – United States, 2023.

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Prevalence of Depression and Anxiety Among Adults With Chronic Pain: A Systematic Review and Meta-Analysis.

Depression and anxiety are common among adults with chronic pain, but their prevalence is unclear.

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Biomechanical analysis of spinal range of motion and intervertebral disc loadings in normal and adolescent idiopathic scoliosis models.

While the Lenke classification enhances our structural understanding of adolescent idiopathic scoliosis (AIS), the biomechanical implications for spinal range of motion (ROM) and intervertebral disc (IVD) loadings remain unclear. This […]

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Pain Sensitivity Questionnaire in Endometriosis.

There is increasing recognition that nociplastic pain and central sensitization may play a role in endometriosis-associated pain. The Pain Sensitivity Questionnaire Minor (PSQ-M) evaluates subjective widespread pain sensitivity, and is […]

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Inflammatory pain modifies reward preferences from larger delayed to smaller immediate rewards in male rats.

Self-control underlies goal-directed behavior in both humans and rodents. The ability to balance immediate and delayed gratification is essential for fine-tuning decision-making processes to achieve optimal rewards. Although delayed gratification […]

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