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Single-nuclei RNA Sequencing Reveals Distinct Transcriptomic Signatures of Rat Dorsal Root Ganglia in a Chronic Discogenic Low Back Pain Model.

Chronic low back pain (LBP), often correlated with intervertebral disc degeneration, is a leading source of disability worldwide yet remains poorly understood. Current treatments often fail to provide sustained relief, […]

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Medical Cannabis in the United States: Comparing 2017 and 2024 State Qualifying Conditions to the 2017 National Academies of Sciences Report.

To compare the 2017 National Academies of Sciences, Engineering, and Medicine cannabis report to state medical cannabis (MC) laws defining approved qualifying conditions (QC) from 2017 and 2024 and to […]

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Fecal calprotectin levels in patients with fibromyalgia: A cross-sectional study.

This study aimed to evaluate levels of fecal calprotectin (FC), a biomarker that helps distinguish irritable bowel syndrome from inflammatory gut disorders, in patients with fibromyalgia syndrome (FMS) and compare […]

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Editorial: Phantom pain: mechanisms and updates in management.

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Resveratrol in ulcerative colitis: therapeutic mechanisms, animal model evidence and novel approaches.

Ulcerative colitis is a type of chronic inflammatory bowel disease characterised by abdominal pain, bloody diarrhoea, rectal bleeding and ulcerations in colon. This illness has significant health risks as it […]

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The Effect of Acupuncture on the Morphology and Neural Coding Damage of the Central Amygdala in Mice with Chronic Inflammatory Pain and Depression.

Observing the effects and roles of acupuncture on the morphology and neural coding damage of central amygdala (CeA) neurons in chronic inflammatory pain with depression (CIPD) mice and exploring the […]

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Nano Drug Delivery Carriers (Nanocarriers): A Promising Targeted Strategy in Tuberculosis and Pain Treatment.

Tuberculosis (TB) and chronic pain are global health concerns that affect millions of people, often requiring long-term, effective treatment strategies. The conventional therapies used to manage these conditions come with […]

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Offset analgesia as a marker of dysfunctional pain modulation in episodic and chronic migraine.

The offset analgesia phenomenon refers to the disproportionately large decrease in the perceived pain following a slight decrease in intensity of a noxious heat stimulus. It is considered an expression […]

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Improvement in the Cognitive Function in Chronic Pain: Therapeutic Potential of the Endocannabinoid System.

Chronic pain presents as a complex condition encompassing sensory (Zhang Z et al. Cell Rep 12;752-759, 2015) and emotional components, often accompanied by anxiety, depression, insomnia, and cognitive impairment. These factors […]

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The effects of chronic stretch training on musculoskeletal pain.

One of the primary mechanisms for the increase in range of motion following stretching is an increase in pain/stretch tolerance. However, it remains unclear whether stretching can reduce pain in […]

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