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Migraine in women: a review.

The purpose of this review is to provide an update on the clinical course and management of migraine in women.

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A distributed coding logic for thermosensation and inflammatory pain.

Somatosensory neurons encode detailed information about touch and temperature and are the peripheral drivers of pain. Here by combining functional imaging with multiplexed in situ hybridization, we determined how heat […]

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Toward Predictive Models of Biased Agonists of the Mu Opioid Receptor.

The mu-opioid receptor (MOR), a member of the G-protein-coupled receptor superfamily, is pivotal in pain modulation and analgesia. Biased agonism at MOR offers a promising avenue for developing safer opioid […]

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Complex Regional Pain Syndrome: Navigating Diagnostic Complexities.

Complex Regional Pain Syndrome (CRPS) presents significant diagnostic challenges due to its diverse clinical presentation. This study aims to describe the diagnostic trajectory of patients labeled with CRPS, focusing on […]

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Electrical Stimulation of the M1 Activates Somatostatin Interneurons in the S1: Potential Mechanisms Underlying Pain Suppression.

Chronic pain affects millions globally, yet no universally effective treatment exists. The primary motor cortex (M1) has been a key target for chronic pain therapies, with electrical stimulation of the […]

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A neural circuit for sex-dependent conditioned pain hypersensitivity in mice.

The neural mechanisms underlying sex-specific pain, in which males and females exhibit distinct responses to pain, remain poorly understood. Here we show that in a mouse model of male-specific pain […]

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A sensory-motor-sensory circuit underlies antinociception ignited by primary motor cortex in mice.

Sensory-motor integration is crucial in the processing of chronic pain. The primary motor cortex (M1) is emerging as a promising target for chronic pain treatment. However, it remains elusive how […]

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Earlier onset of chemotherapy-induced neuropathic pain in females by ICAM-1-mediated accumulation of perivascular macrophages.

Sex differences in the pathogenesis of a variety of diseases have drawn increasing attention. However, it remains unclear whether such differences exist in chemotherapy-induced neuropathic pain. Here, we conducted a […]

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Astrocytic GPR37L1: A new guardian against the onset and chronicity of neuropathic pain.

In this issue of Neuron, Xu et al. demonstrate that activating GPR37L1, a G-protein-coupled receptor that negatively regulates astrocytes, suppresses the onset and maintenance of neuropathic pain, an intractable chronic pain […]

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Cannabinoid CB2 receptor controls chronic itch by regulating spinal microglial activation and synaptic transmission

Chronic itch is a devastating clinical condition, and its central mechanisms remain poorly understood. We reported that spinal cannabinoid receptor type 2 (CB2R) activation exerts antipruritic effects and that itch […]

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