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Pain experience of children with Christianson syndrome.

Children with Christianson syndrome (CS), an X-linked neurodevelopmental disorder caused by loss-of-function mutations in the alkali cation/proton exchanger SLC9A6/NHE6, display severe cognitive impairments, mutism, and sensory abnormalities such as hyposensitivity […]

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Sodium Butyrate ameliorates pain and mood disorders in a mouse model of Parkinson disease.

Pain is one of non-motor features of Parkinson’s disease (PD) that significantly impacts on patients’ quality of life and increases the risk of developing psychiatric disorders. The mechanisms underlying pain […]

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Current opinion: an overview of sickle cell disease and chronic pain and perioperative considerations.

This review aims to provide the practicing anesthesiologist with information on the pathophysiology, physiology, and management of patients with sickle cell disease. This includes the evaluation of common intraoperative management […]

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Chronification of migraine sensitizes to CGRP in male and female mice.

Acute therapies targeting calcitonin gene-related peptide (CGRP) for episodic migraine (EM) demonstrate efficacy in women, but evidence of efficacy in men remains to be established. By contrast, CGRP targeting therapies […]

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Editorial: Advances in the pharmacotherapy of chronic pelvic pain conditions.

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Psychedelics and chronic pain: self-reported outcomes on changed substance use patterns and health following naturalistic psychedelic use.

Psychedelic substances have shown preliminary efficacy for several neuropsychiatric disorders and are currently being investigated for chronic pain conditions. However, few studies have investigated outcomes of naturalistic psychedelic use among […]

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Towards a better definition of nociplastic pain conditions: a psychological grounded study on fibromyalgia, chronic headache and vulvodynia.

This study investigates the psychological underpinnings of chronic pain conditions, specifically fibromyalgia, chronic headache, vulvodynia, and mixed condition (consisting of fibromyalgia in comorbidity with chronic headache and/or vulvodynia), with a […]

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Indole-2-Carboxamide as an Effective Scaffold for the Design of New TRPV1 Agonists.

Due to its central role in pain, inflammation, and related disorders, the Transient Receptor Potential (TPR) Vanilloid Type-1 (TRPV1) ion channel represents an attractive target for the development of novel […]

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Long-Term Headache Outcome and Radiological Correlates in Patients With Intracranial Hypotension.

Headache is the most common presenting symptom of intracranial hypotension (IH), and it usually has orthostatic features. However, the outcome of IH and the persistence and characteristics of headache are […]

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Graded activity for chronic low back pain.

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of graded activity compared to placebo, sham, or no treatment […]

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