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Antimigraine activity of Asarinin by OPRM1 pathway with multifaceted impacts through network analysis.

Migraine is a debilitating neurological disorder impacting millions worldwide. Calcitonin Gene-Related Peptide (CGRP) has emerged as a key player in migraine pathophysiology, leading to the development of targeted therapies. This […]

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Ultraconformable cuff implants for long-term bidirectional interfacing of peripheral nerves at sub-nerve resolutions.

Implantable devices interfacing with peripheral nerves exhibit limited longevity and resolution. Poor nerve-electrode interface quality, invasive surgical placement and development of foreign body reaction combine to limit research and clinical […]

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Exploring the perceptions of senior medical students on gender and pain: a qualitative study of the interplay between formal and hidden curricula.

Explore the perceptions of senior medical students on the relationship between gender and pain and examine how formal and hidden curricula in medical education shape their experiences.

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Healthcare Discrimination Affects Patient Activation, Communication Self-efficacy, and Pain for Black Americans.

This study examines whether a key psychosocial factor-perceiving racial discrimination in healthcare-is associated with worse patient activation, communication self-efficacy, and physical health outcomes for Black veterans with chronic pain. Moreover, […]

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The anti-inflammatory and immunomodulatory effects of olfactory ensheathing cells transplantation in spinal cord injury and concomitant pathological pain.

Spinal cord injury (SCI) is a serious and disabling injury that is often accompanied by neuropathic pain (NeP), which severely affects patients’ motor and sensory functions and reduces their quality […]

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Childhood trauma, PTSD/CPTSD and chronic pain: A systematic review.

Despite the growing body of literature on posttraumatic stress disorder (PTSD) and chronic pain comorbidity, studies taking into account the role of childhood exposure to traumatic and adverse events remains […]

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Glucocorticoid signaling mediates stress-induced migraine-like behaviors in a preclinical mouse model.

Stress is one of the most common precipitating factors in migraine and is identified as a trigger in nearly 70% of patients. Responses to stress include release of glucocorticoids as […]

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Evaluating the Current Evidence for the Efficacy of Cannabis in Symptom Management of Endometriosis-Associated Pain.

Endometriosis is a chronic condition that affects millions of women in the United States. Chronic pain can be debilitating and complex to manage. Despite common approaches like hormonal treatments and […]

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The intersection of endocrine signaling and neuroimmune communication regulates neonatal nociception.

Neonatal pain is a significant clinical issue but the mechanisms by which pain is produced early in life are poorly understood. Our recent work has linked the transcription factor serum […]

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Prevention and Reversal of Neuropathic Pain by Near-Infrared Photobiomodulation Therapy in Male and Female Rats.

Pathological nociception arising from peripheral nerve injury impacts quality of life. Current therapeutics are generally ineffective. However, photobiomodulation therapy (PBMT) has shown promise in addressing this issue. We aimed to […]

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