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Atopic Dermatitis (AD) is a multifaceted inflammatory skin disease characterized by chronic itch and Acute Itch Flare (AIF), with basophils playing pivotal roles in both. While VAMP7 (V7) mediates immune […]
Difficult encounters represent an enormous burden and drain on resources in pain medicine, but their effect on outcome has not been studied.
The pituitary adenylate cyclase-activating peptide (PACAP) pathway is a critical focus in the pathophysiology of several headache disorders. PACAP influences headache pathophysiology through interactions with distinct receptors (PAC, VPAC, and […]
Many wounds can be challenging to manage because of pain and poor angiogenesis. An ideal treatment for such wounds would be a gel that can induce angiogenesis to accelerate wound […]
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating chronic condition characterized by pelvic pain and urinary disturbances, making its diagnosis challenging due to overlapping symptoms with various lower urinary tract […]
Acute pain, a critical aspect of patient care, presents a challenge due to its subjective nature and complex biological underpinnings. Biomarkers for acute pain promise a paradigm shift in how […]
Osteoarthritis (OA) is associated with inflammatory responses linked to microglial polarisation within the central nervous system. However, exploring therapeutic approaches and their underlying mechanisms remains a direction for future research. […]
Osteoarthritis (OA), a prevalent and disabling condition, significantly burdens individuals and healthcare systems worldwide. It is characterized by joint pain, stiffness, and structural changes in cartilage, bone, and synovium. The […]
Transient receptor potential melastatin 8 (TRPM8), a gene encoding a nonselective cation channel responsive to cold stimuli, has been implicated in migraine susceptibility. Despite this association, the role of TRPM8 […]