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The reported prevalence of chronic pain after spinal cord injury (SCI) varies widely due, in part, to differences in the taxonomy of chronic pain. A widely used classification system is available to describe subcategories of chronic pain in SCI, but the prevalence of chronic pain in SCI based on this system is unknown.
Learn More >To characterize suicidality among youth with juvenile fibromyalgia syndrome (JFMS) receiving treatment from pediatric rheumatologists at a tertiary care center in order to determine the prevalence of suicidality in JFMS and to explore risk factors for persistent suicidal ideation.
Learn More >Opioid use and chronic pain are prevalent in the veteran population. Collaborative Care enhances coordination between patients and their care teams and Motivational Interviewing (MI) is a communication style designed to facilitate behavior change. This study evaluated the use of Collaborative Care with MI (CCMI) with patients with chronic pain and high-risk prescription opioid use.
Learn More >Chronic pain is associated with significant physical and psychological impairments across the adult lifespan. However, there is a relative gap in knowledge on individual differences that predict pain-related functioning. The current study highlights one important source of individual variation: age.
Learn More >The aim of this study was to collect and rate Green Flags, that is, symptoms or pieces of information indicating that a patient is more likely to suffer from a primary than from a secondary headache.
Learn More >The adolescent years represent a key period for the development of musculoskeletal complaints (MSC) and the differences between boys and girls. We evaluated the prevalence and course of MSC and factors associated with MSC while growing up from age 11 to age 20.
Learn More >This study determines the prevalence and particularities of headache and pain with neuropathic characteristics (NC) in a large French group of patients with pituitary adenoma (PA).
Learn More >To study the agreement between self-reported trigger factors and early premonitory symptoms amongst a group of migraineurs in both spontaneous and pharmacologically provoked attacks.
Learn More >The primary aim of this randomized clinical trial is to investigate the effects of ultrasound guided transversus abdominis plane (TAP) versus ultrasound guided trigger point injections (TPIs) on numerical rating scale (NRS) pain scores at month 3 follow-up in patients with a chronic abdominal wall pain (AWP). The primary outcome measure was the difference in mean numeric rating scale pain scores between the TAP and TPI groups at month 3 in an intent-to-treat (ITT) analysis. A total of 60 patients were randomized 1:1 to receive an ultrasound-guided TAP block (n=30) or an ultrasound-guided TPI (n=30). No significant group differences in baseline demographic or clinical characteristics were observed. The mean baseline pain score for the TAP and TPI groups were 5.5 and 4.7, respectively. In the ITT analysis at month 3, the between group difference in pain scores was 1.7 (95% CI, 0.3 to 3.0) favoring the TPI group. In a secondary per-protocol analysis, the between group difference in pain scores was 1.8 (95% CI, 0.4 to 3.2) favoring the TPI group. For the ITT and per-protocol analyses, the group differences in pain scores were consistent with a medium effect size. The main finding of this randomized clinical trial is that adults with chronic AWP who received a TPI reported significantly lower pain scores at month 3 follow-up compared to patients who received a TAP block.
Learn More >Pain puts patients at risk for developing psychiatric conditions such as anxiety and depression. Pre-clinical mouse models of pain-induced affective behavior vary widely in methodology and results, impairing progress towards improved therapeutics. To systematically investigate the effect of long-term inflammatory pain on exploratory behavior and stress coping strategy, we assessed male C57BL/6J mice in the forced swim test (FST), elevated zero maze (EZM), and open field test (OFT) at four and six weeks post-injection of Complete Freund's Adjuvant (CFA), while controlling for testing order and combination. Inflammatory pain did not induce a passive stress coping strategy in the FST and did not reduce exploratory behavior in the EZM or the OFT. Using systematic correlational analysis and composite behavioral scores, we found no consistent association among measures for mice with or without inflammatory pain. A meta-analysis of similar studies indicated a modest, significant effect of CFA on exploratory behavior, but not immobility in the FST, and high heterogeneity among effect sizes in all three paradigms. Given the urgency for understanding the mechanisms of pain comorbidities and identifying novel therapies, these findings support the reallocation of our limited resources away from such unreliable assays and toward motivated and naturalistic behaviors. Future studies in pain and psychiatric translational research may benefit by considering outcomes beyond binary categorization, quantifying the associations between multiple measured behaviors, and agnostically identifying subtle yet meaningful patterns in behaviors.
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