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Papers of the Week


Papers: 9 Jan 2021 - 15 Jan 2021

PAIN TYPE:
Itch


2021 Jan 06


Neurosci Lett

The Role of Mrgprs in Pain.

Authors

Green DP
Neurosci Lett. 2021 Jan 06:135544.
PMID: 33421487.

Abstract

Owing to their functional diversity, the Mas-related G-protein-coupled receptor (Mrgpr) family has a role in both itch and pain modulation. While primarily linked to pruritis, Mrgprs were originally characterized in small-diameter nociceptive neurons of dorsal root ganglia (DRG) and trigeminal ganglia. This review will focus on the role Mrgpr's have in pain physiology, discussing recent discoveries as well as how Mrgpr's may provide a new target for the treatment of pathological pain.