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Papers of the Week

Papers: 9 Jan 2021 - 15 Jan 2021


2021 Jan 06

Neurosci Lett

The Role of Mrgprs in Pain.


Green DP
Neurosci Lett. 2021 Jan 06:135544.
PMID: 33421487.


Owing to their functional diversity, the Mas-related G-protein-coupled receptor (Mrgpr) family has a role in both itch and pain modulation. While primarily linked to pruritis, Mrgprs were originally characterized in small-diameter nociceptive neurons of dorsal root ganglia (DRG) and trigeminal ganglia. This review will focus on the role Mrgpr's have in pain physiology, discussing recent discoveries as well as how Mrgpr's may provide a new target for the treatment of pathological pain.