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Headache research in 2024: new data on migraine prevention.

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Altered surface-based brain morphometry in type 1 diabetes and neuropathic pain.

This study explored surface brain morphometry in type 1 diabetes including focus on painful diabetic peripheral neuropathy (DPN). Brain MRI was obtained from 56 individuals with diabetes (18 without DPN, […]

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Hormonal mechanisms in the paraventricular nuclei associated with hyperalgesia in Parkinson’s disease model rats.

Pain is a major non-motor symptom of Parkinson’s disease (PD). The relationship between hyperalgesia and neuropeptides originating from paraventricular nucleus (PVN) in 6-hydroxydopamine (6-OHDA) rats has already been investigated for […]

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Recent advances in the treatment of chronic pain and substance use disorders.

Among people with substance use disorders (SUDs), chronic pain is among the most common comorbid chronic health conditions. Chronic pain increases risk for poor SUD treatment outcomes, including risk for […]

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Role of TLR4 activation and signaling in bone remodeling, and afferent sprouting in serum transfer arthritis.

In the murine K/BxN serum transfer rheumatoid arthritis (RA) model, tactile allodynia persists after resolution of inflammation in male and partially in female wild type (WT) mice, which is absent […]

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Recent Advances in enhancer of zeste homolog 2 Inhibitors: Structural insights and therapeutic applications.

Enhancer of Zeste Homolog 2 (EZH2) is overexpressed in many malignancies and plays a critical role in cancer progression. Therefore, it is considered a promising target for therapeutic intervention. Although […]

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Pain can’t be carved at the joints: defining function-based pain profiles and their relevance to chronic disease management in healthcare delivery design.

Pain is a complex problem that is triaged, diagnosed, treated, and billed based on which body part is painful, almost without exception. While the “body part framework” guides the organization […]

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Cannabidiol induces autophagy via CB receptor and reduces α-synuclein cytosolic levels.

Numerous studies have explored the role of cannabinoids in neurological conditions, chronic pain and neurodegenerative diseases. Restoring autophagy has been proposed as a potential target for the treatment of neurodegenerative […]

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Microglia in the aged brain develop a hypoactive molecular phenotype after surgery.

Microglia, the resident immune cells of the brain, play a crucial role in maintaining homeostasis in the central nervous system (CNS). However, they can also contribute to neurodegeneration through their […]

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Association between migraine and mitochondria: A Mendelian randomization study.

Mitochondria are important organelles functioning in metabolic processes, inflammatory response and neurological disorders. Migraines are chronic and paroxysmal neurological disorders characterized by recurrent episodes of severe headache and other neurological […]

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