Browse by Audience
Skip to content
Papers of the Week
Role of TLR4 activation and signaling in bone remodeling, and afferent sprouting in serum transfer arthritis.
Authors
Dos Santos GG, Jiménez-Andrade JM, Muñoz-Islas E, Candanedo-Quiroz ME, Cardenas AG, Drummond B, Pham P, Stilson G, Hsu CC, Delay L, Navia-Pelaez JM, Lemes JP, Miller YI, Yaksh TL, Corr MAbstract
In the murine K/BxN serum transfer rheumatoid arthritis (RA) model, tactile allodynia persists after resolution of inflammation in male and partially in female wild type (WT) mice, which is absent in Toll-like receptor (TLR)4 deficient animals. We assessed the role of TLR4 on allodynia, bone remodeling and afferent sprouting in this model of arthritis.