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Prevalence of depression and anxiety in women with chronic pelvic Pain: A systematic review and Meta-Analysis.

This study aimed to present the prevalence of depression and anxiety in women with Chronic Pelvic Pain (CPP) and their associated factors.

Mendelian randomization analysis reveals causal effects of migraine and its subtypes on early-onset ischemic stroke risk.

Previous observational studies have suggested at a potential link between migraine, particularly migraine with aura, and the susceptibility to early-onset ischemic stroke. We aimed to investigate the causal effects of […]

iPSC-derived human sensory neurons reveal a subset of TRPV1 antagonists as anti-pruritic compounds.

Signaling interplay between the histamine 1 receptor (H1R) and transient receptor potential cation channel subfamily V member 1 (TRPV1) in mediating histaminergic itch has been well-established in mammalian models, but […]

PGE and HCN2 ion channels are critical mediators of pain initiated by angiotensin II.

Angiotensin II is well known to have an important influence on blood pressure, mediated via the angiotensin II type 1 receptor (AT1R), and more recent studies have shown that angiotensin […]

Vestibular Migraine Patient Assessment Tool and Handicap Inventory (VM-PATHI) : A narrative review.

Vestibular migraine (VM) has a wide range of clinical presentations that can have a significant negative impact on quality of life. Currently, there is no objective test available to confirm […]

Temporal changes of spinal microglia in murine models of neuropathic pain: a scoping review.

Neuropathic pain (NP) is an ineffectively treated, debilitating chronic pain disorder that is associated with maladaptive changes in the central nervous system, particularly in the spinal cord. Murine models of […]

Transient destabilization of interhemispheric functional connectivity induced by spreading depolarization.

Cortical spreading depolarization (CSD), a slowly propagating wave of transient cellular depolarization, is a reliable cortical response to various brain insults (stroke, trauma, seizures) and underlying mechanism of migraine aura. […]

Comprehensive list of preventative migraine headache medications without significant drug-drug interactions.

Preventive medications are crucial in migraine prevention. In cases of refractory migraine headaches, multiple medications may be required. We seek to identify a comprehensive list of preventive migraine headache medications […]

Evidence for spinal disinhibition as a pain-generating mechanism in fibromyalgia syndrome.

Pain phenomenology in patients with fibromyalgia syndrome (FMS) shows considerable overlap with neuropathic pain. Altered neural processing leading to symptoms of neuropathic pain can occur at the level of the […]

Predictors of anxiety in endometriosis patients.

To evaluate the main factors influencing anxiety in endometriosis patients presenting to an endometriosis centre in Germany.

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