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Papers of the Week
Evidence for spinal disinhibition as a pain-generating mechanism in fibromyalgia syndrome.
Authors
Marshall A, Burgess J, Goebel A, Frank B, Alam U, Marshall AAbstract
Pain phenomenology in patients with fibromyalgia syndrome (FMS) shows considerable overlap with neuropathic pain. Altered neural processing leading to symptoms of neuropathic pain can occur at the level of the spinal cord, and 1 potential mechanism is spinal disinhibition. A biomarker of spinal disinhibition is impaired H-reflex rate-dependent depression (HRDD).