Browse by Audience
The present meta-analysis analyzed the efficacy and safety of wrist-ankle acupuncture (WAA) as an additional therapy for postoperative multimodal analgesia following orthopedic surgery.
Learn More >To identify changes in opioid prescribing across a diverse array of medical specialties following release of the 2016 CDC Guideline for Prescribing Opioids for Chronic Pain.
Learn More >Soft polymer nanoparticles designed to disassemble and release an antagonist of the neurokinin 1 receptor (NKR) in endosomes provide efficacious yet transient relief from chronic pain. These micellar nanoparticles are unstable and rapidly release cargo, which may limit the duration of analgesia. We examined the efficacy of stable star polymer nanostars containing the NKR antagonist aprepitant-amine for the treatment of chronic pain in mice. Nanostars continually released cargo for 24 h, trafficked through the endosomal system, and disrupted NKR endosomal signaling. After intrathecal injection, nanostars accumulated in endosomes of spinal neurons. Nanostar-aprepitant reversed mechanical, thermal and cold allodynia and normalized nociceptive behavior more efficaciously than free aprepitant in preclinical models of neuropathic and inflammatory pain. Analgesia was maintained for >10 h. The sustained endosomal delivery of antagonists from slow-release nanostars provides effective and long-lasting reversal of chronic pain.
Learn More >We explore recent developments in the prevention and treatment of migraine through dietary interventions.
Learn More >To identify and synthesize the scientific literature on virtual reality (VR)-based mindfulness applications for the management of chronic pain in adults.
Learn More >Acupuncture is an analgesic technique that has long been utilized in Eastern medicine. In recent times, various acupuncture techniques have been used in integrated pain management approaches in Western medicine. It has even been adopted as an analgesic method in surgical patients. Currently, no review exists regarding various acupuncture techniques used in perioperative pain management and data describing the utility of these techniques. This paper synthesizes the latest literature regarding the role of acupuncture in perioperative pain management. The authors sought to describe various acupuncture modalities used to help manage surgical pain and synthesize the current body of literature to help readers make informed judgements on the topic.
Learn More >The impact of rheumatoid arthritis (RA) on the shaping of the oral and gut microbiome raises the question of whether and how RA treatment modifies microbial communities. We examined changes in the oral and gut microbiota in a mouse model of antigen-induced arthritis (AIA) treated or not with methotrexate (MTX).
Learn More >Migraine is a common, debilitating disorder for which attacks typically result in a throbbing, pulsating headache. Although much is known about migraine, its complexity renders understanding the complete etiology currently out of reach. However, two important facts are clear, the brain and the metabolism of the migraineur differ from that of the non-migraineur. This review centers on the altered amino acid metabolism in migraineurs and how it helps define the pathology of migraine.
Learn More >Osteoarthritis (OA) is a chronic joint disease that represents an increasingly substantial global burden. Joint pain is the most significant symptom of OA. Unfortunately, current pharmacological treatments for OA pain are often not wholly efficacious, or are associated with serious adverse effects. This lack of effective pain relief has seen the prescription of opioids for OA pain increase over the past decades. The long-term adverse effects of prescribed opioids alongside the increasing prevalence of OA pain highlights the need for alternative analgesics. Understanding the mechanisms that drive this chronic joint pain is crucial for the development of novel analgesics. OA is a heterogeneous disease, and this is reflected by the diversity of pain phenotypes in people with the disease. Herein, we review current understanding of the biological changes at the joint and within the central nervous system that drive this chronic pain. We particularly focus on the most recent advances in our understanding of the peripheral nociceptive mechanisms that underlie chronic OA pain and highlight how targeting peripheral OA inflammation may open up opportunities for novel analgesics.
Learn More >: Pain is a multidimensional experience involving the biological, psychological, and social dimensions of each individual. Particularly, the biological aspects of pain conditions are a response of the neuroimmunology system and the control of painful conditions is a worldwide challenge for researchers. Although years of investigation on pain experience and treatment exist, the high prevalence of chronic pain is still a fact.
Learn More >