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Papers of the Week

Papers: 30 Apr 2022 - 6 May 2022

Animal Studies

2022 Apr 28


Methotrexate promotes recovery of arthritis-induced alveolar bone loss and modifies the composition of the oral-gut microbiota.


de Arruda J A A, Corrêa J D, Singh Y, Oliveira S R, Machado C C, Schneider A H, Medeiros J D, Fernandes GR, Macari S, Barrioni B R, de Souza Santos M, Duffles L F, Imoto Nakaya H T, Fukada S Y, Graves DT, Cunha F Q, Silva T A
Anaerobe. 2022 Apr 28:102577.
PMID: 35490916.


The impact of rheumatoid arthritis (RA) on the shaping of the oral and gut microbiome raises the question of whether and how RA treatment modifies microbial communities. We examined changes in the oral and gut microbiota in a mouse model of antigen-induced arthritis (AIA) treated or not with methotrexate (MTX).