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A new vision of the role of the cerebellum in pain processing.

The cerebellum is a structure in the suprasegmental nervous system classically known for its involvement in motor functions such as motor planning, coordination, and motor learning. However, with scientific advances, […]

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Marine-derived bioactive compounds for neuropathic pain: pharmacology and therapeutic potential.

Neuropathic pain, a challenging condition often associated with diabetes, trauma, or chemotherapy, impairs patients’ quality of life. Current treatments often provide inconsistent relief and notable adverse effects, highlighting the urgent […]

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Activation of δ-opioid receptors blocks allodynia in a model of headache induced by PACAP.

Pituitary adenylate cyclase activating polypeptide (PACAP) is a human migraine trigger that is being targeted for migraine. The δ-opioid receptor (δ-receptor) is a novel target for the treatment of migraine, […]

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Hypnosis Sedation Used in Breast Oncologic Surgery Significantly Decreases Perioperative Inflammatory Reaction.

Hypnosis sedation has recently been used for anesthesia in breast oncologic surgery.

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Chronic Gastrointestinal Disorders and miRNA-Associated Disease: An Up-to-Date.

Chronic gastrointestinal disorders such as inflammatory bowel diseases (IBDs) and irritable bowel syndrome (IBS) impose significant health burdens globally. IBDs, encompassing Crohn’s disease and ulcerative colitis, are multifactorial disorders characterized […]

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Diffuse Noxious Inhibitory Controls in Chronic Pain States: Insights from Pre-Clinical Studies.

Diffuse noxious inhibitory control (DNIC), also known as conditioned pain modulation (CPM) in humans, is a paradigm wherein the heterotopic application of a noxious stimulus results in the attenuation of […]

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Pregabalin is associated with a higher overdose risk but the risk with gabapentin is not negligible.

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Bugs take the sting out.

Jiang et al. investigate the role of the microbiota in postherpetic neuralgia (PHN), a chronic pain condition resulting from varicella-zoster virus reactivation. They identify microbiome alterations in PHN patients, linking microbes […]

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Chronic postsurgical pain in pediatric patients: perioperative risk factors and preventive actions.

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Pharmacological and non-pharmacological interventions for pain control in outpatient hysteroscopy: A systematic review.

Outpatient hysteroscopy (OPH) is an important diagnostic and therapeutic intervention in gynaecology. However, the most common reason for failure is pain. Currently, there is no consensus regarding analgesia for OPH […]

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