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Treatment Expectations and Pain-Related Outcomes in Clinical Trials of Digital Cognitive Behavioral Therapy for Youth with Chronic Pain.

Treatment expectations (TE) are predictive of patient outcomes in clinical practice and suggested to moderate treatment responses in chronic pain clinical trials. However, evidence is mainly derived from studies conducted […]

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Functional MRI reveals brain activation patterns associated with optimization of spinal cord stimulation parameters in treating chronic pain.

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Accessibility of psychological treatments for chronic pain in low socioeconomic settings.

Chronic pain is a highly prevalent condition globally. Low-socioeonomic (SES) populations tend to have higher prevalence rates and worsened pain outcomes. Although psychological interventions for chronic pain are considered an […]

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Cut-Off Values Able to Identify Migraine Patients With Increased Pressure-Pain Sensitivity Independent of the Migraine Cycle Through a Single Assessment: A Secondary Analysis of a Multicentre, Cross-Sectional, Observational Study.

Identify values that could predict the presence of increased pressure-pain sensitivity independent of the migraine cycle through a single assessment.

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Nociceptor sodium channels shape subthreshold phase, upstroke, and shoulder of action potentials.

Voltage-gated sodium channels (VGSCs) in the peripheral nervous system shape action potentials (APs) and thereby support the detection of sensory stimuli. Most of the nine mammalian VGSC subtypes are expressed […]

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What does pain sensitivity really predict in rheumatoid arthritis patients?

The present study aimed to compare the pressure-pain threshold (PPT) values in patients with rheumatoid arthritis (RA) and age-gender matched controls with chronic nonspecific low back pain and to determine […]

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Nav1.8, an analgesic target for nonpsychotomimetic phytocannabinoids.

Pain impacts billions of people worldwide, but treatment options are limited and have a spectrum of adverse effects. The search for safe and nonaddictive pain treatments has led to a […]

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Evidence-Based Umbrella Review of Non-Invasive Neuromodulation in Chronic Neuropathic Pain.

Non-invasive neuromodulation techniques (NIN), such as transcranial Direct Current Stimulation (tDCS) and repetitive Transcranial Magnetic Stimulation (rTMS), have been extensively researched for their potential to alleviate pain by reversing neuroplastic […]

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An evidence-based update on the diagnosis and management of irritable bowel syndrome.

Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction affecting 5% of the population. The cardinal symptoms are abdominal pain and altered stool form or frequency.

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Autoantibodies cause nociceptive sensitization in a mouse model of degenerative osteoarthritis.

Previous preclinical and translational studies suggest that tissue trauma related to bony fracture and intervertebral disk disruption initiates the formation of pronociceptive antibodies that support chronic musculoskeletal pain conditions. This […]

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