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Label-free serum proteomics for the identification of the putative biomarkers of postoperative pain in patients with gastric cancer.

: Individualized pain therapy conforms to the concept of precision medicine and contributes to adequate pain management after surgery. Preoperative biomarkers associated with postoperative pain may instruct anesthesiologists to improve […]

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Odevixibat: A Review of a Bioactive Compound for the Treatment of Pruritus Approved by the FDA.

Odevixibat is synthesized through chemical modification of Benzothiazepine’s structure. It is a tiny chemical that inhibits the ileal bile acid transporter and is used to treat a variety of cholestatic […]

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Sex differences in chronic pain-induced mental disorders: Mechanisms of cerebral circuitry.

Mental disorders such as anxiety and depression induced by chronic pain are common in clinical practice, and there are significant sex differences in their epidemiology. However, the circuit mechanism of […]

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Pain Control with Regional Anesthesia in Patients at Risk of Acute Compartment Syndrome: Review of the Literature and Editorial View.

Acute compartment syndrome (ACS) is a devastating complication that can happen in almost every part of the human body, most noticeably after long bone fractures. The cardinal symptom of ACS […]

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Cutaneous manifestations associated with immune checkpoint inhibitors.

Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that block key mediators of tumor-mediated immune evasion. The frequency of its use has increased rapidly and has extended to numerous cancers. ICIs […]

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Chronic pain and local pain in usually painless conditions including neuroma may be due to compressive proximal neural lesion.

It has been unexplained why chronic pain does not invariably accompany chronic pain-prone disorders. This question-driven, hypothesis-based article suggests that the reason may be varying occurrence of concomitant peripheral compressive […]

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Modulation effects of different treatments on periaqueductal gray resting state functional connectivity in knee osteoarthritis knee pain patients.

The analgesic effect of acupuncture is widely recognized, but the mechanical characteristics of acupuncture for pain relief, compared to non-steroidal anti-inflammatory (NSAIDs) and placebo medication, remain unknown.

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Decrease in current perception thresholds of A-beta fibers by subthreshold noise stimulation using transcutaneous electrical nerve stimulation.

Developing effective supplements and rehabilitation of the impaired tactile and proprioception sensation is a significant challenge. One potential method for improving these sensations in clinical practice is using stochastic resonance […]

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Pediatrician explanations of pediatric pain in clinical settings: A delicate craft.

Explaining chronic pain to children and families can be challenging, particularly in the absence of an obvious physiologically identifiable cause for the child’s pain. In addition to medical intervention, children […]

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Mindfulness and Chronic Musculoskeletal Pain: An Umbrella Review.

Chronic musculoskeletal pain (CMSP) disorders are a leading cause of disability globally, affecting up to one in three people. Mindfulness-based interventions (MBI) have become a popular treatment for CMSP. The aim […]

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