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Scientific rationale for the use of α2A-adrenoceptor agonists in treating neuroinflammatory cognitive disorders.

Neuroinflammatory disorders preferentially impair the higher cognitive and executive functions of the prefrontal cortex (PFC). This includes such challenging disorders as delirium, perioperative neurocognitive disorder, and the sustained cognitive deficits […]

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Treating Chronic Pain in Sickle Cell Disease – The Need for a Biopsychosocial Model.

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Problems With O’Connell et al “Implanted Spinal Neuromodulation Interventions for Chronic Pain in Adults” (Cochrane Review).

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Multi-region local field potential signatures and brain coherence alternations in response to nitroglycerin-induced migraine attacks.

To decipher the underlying mechanisms of nitroglycerin (NTG)-induced migraine electrophysiologically.

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Efficient elimination of phenazone by an electro-assisted Fe-EDDS/PS process at neutral pH: Kinetics, mechanistic insights and toxicity evaluation.

The feasibility of the degradation of phenazone (PNZ), a common anti-inflammatory drug used for reducing pain and fever, in water at neutral pH by an electrochemically assisted Fe-ethylenediamine disuccinate-activated persulfate […]

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In situ delivery of a curcumin-loaded dynamic hydrogel for the treatment of chronic peripheral neuropathy.

Patients with peripheral nerve injuries would highly likely suffer from chronic neuropathic pain even after surgical intervention. The primary reasons for this involve sustained neuroinflammatory and dysfunctional changes in the […]

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High Intensity-Transcutaneous Electrical Nerve Stimulation Does Not Inhibit Temporal Summation of the Nociceptive Flexion Reflex.

Pain facilitation contributes to chronic pain conditions. Transcutaneous electrical nerve stimulation (TENS) is used to alleviate pain. The effects of conventional TENS on chronic pain have been limited, and its […]

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Pain-Related Anxiety in Spanish-Speaking Mexican Americans who Report Chronic Pain: Psychometric Evaluation of a New Spanish Adaptation of the 20-Item Pain Anxiety Symptom Scale (PASS-20).

The 20-item Pain Anxiety Symptom Scale (PASS-20) was adapted for Spanish-speaking Mexican Americans who report chronic pain (SSMACP). The instrument measures pain-related anxiety with fear, physiological, avoidance/escape, and cognitive anxiety […]

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Classical and Non-Classical Psychedelic Drugs Induce Common Network Changes in Human Cortex.

The neurobiology of the psychedelic experience is not fully understood. Identifying common brain network changes induced by both classical (i.e., acting at the 5-HT receptor) and non-classical psychedelics would provide […]

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Autologous mesenchymal stem cell transplantation for spinal fusion: 10 years follow-up of a phase I/II clinical trial.

Posterolateral spinal fusion is the standard surgical approach for patients with degenerative disc disease. In our previously published article, we reported a 5-years follow-up of a phase I/II clinical trial […]

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