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Forecasting migraine with machine learning based on mobile phone diary and wearable data.

Triggers, premonitory symptoms and physiological changes occur in the preictal migraine phase and may be used in models for forecasting attacks. Machine learning is a promising option for such predictive […]

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Low back pain of disc, sacroiliac joint, or facet joint origin: a diagnostic accuracy systematic review.

The accuracy of diagnostic tests available in primary care to identify the disc, sacroiliac joint, and facet joint as the source of low back pain is uncertain.

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Transvenous occlusion of incompetent pelvic veins to treat chronic pelvic pain in women: A randomised controlled trial.

To investigate the effectiveness of transvenous occlusion of incompetent pelvic veins in women presenting with chronic pelvic pain (CPP) in improving symptoms and quality of life.

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FACILITATED CENTRAL PAIN MECHANISMS ACROSS THE MENSTRUAL CYCLE IN DYSMENORRHEA AND ENLARGED PAIN DISTRIBUTION IN WOMEN WITH LONGER PAIN HISTORY.

Dysmenorrhea, or recurrent menstrual pain, is a highly prevalent pain condition among otherwise healthy women. However, the progression of dysmenorrhea over time and the influence of the menstrual cycle phases […]

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Peripheral nerve stimulation enables somatosensory feedback while suppressing phantom limb in transradial amputees.

To simultaneously treat phantom limb pain (PLP) and restore somatic sensations using peripheral nerve stimulation (PNS), two bilateral transradial amputees were implanted with stimulating electrodes in the proximity of the […]

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Acetaldehyde via CGRP receptor and TRPA1 in Schwann cells mediates ethanol-evoked periorbital mechanical allodynia in mice: relevance for migraine.

Ingestion of alcoholic beverages is a known trigger of migraine attacks. However, whether and how ethanol exerts its pro-migraine action remains poorly known. Ethanol stimulates the transient receptor potential vanilloid […]

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Validation of σ R/TMEM97 as a neuropathic pain target: Specificity, human expression and mechanism of action.

The Sigma 2 receptor (σ R) was described pharmacologically more than three decades ago, but its molecular identity remained obscure until recently when it was identified as transmembrane protein 97 […]

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Periaqueductal grey and spinal cord pathology contribute to pain in Parkinson’s disease.

Pain is a key non-motor feature of Parkinson’s disease (PD) that significantly impacts on life quality. The mechanisms underlying chronic pain in PD are poorly understood, hence the lack of […]

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PX and P2Y receptor antagonists reduce inflammation in ATP-induced microglia.

P2 receptors have been implicated in the release of neurotransmitter and pro-inflammatory cytokines due to their response to neuro-excitatory substances in the microglia. The P2X4, P2X7 and P2Y12 receptors are […]

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Exploring sex as a moderator of other prognostic variables in whiplash associated disorder: An observational study.

Prognostic variables for assessing people with whiplash associated disorder (WAD) following a motor vehicle collision (MVC) have been evaluated in numerous studies. However, there is minimal evidence assessing how these […]

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