I am a
Home I AM A Search Login

Accepted

Share this

Antidepressants lack evidence for treating chronic pain, says Cochrane.

Learn More >

A Gain-of-function Mutation in the Gating Domain of ITPR1 Impairs Motor Movement and Increases Thermal and Mechanical Sensitivity.

Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) is an intracellular Ca release channel important for a number of fundamental cellular functions. Consistent with its critical physiological significance, mutations in ITPR1 are […]

Learn More >

Neurotrophins and their receptors, novel therapeutic targets for pelvic pain in endometriosis, are coordinately regulated by interleukin-1β via the JNK signaling pathway.

Pelvic pain in women with endometriosis is attributed to neuroinflammation and afferent nociceptor nerves in ectopic and eutopic endometrium. The hypothesis that uterine nociception is activated by IL-1β, a prominent […]

Learn More >

Folic acid relieves bone cancer pain by downregulating P2X2/3 receptors in rats.

Bone cancer pain (BCP) remains a clinical challenge due to the limited and side effects of therapeutic methods. Folic acid has been known as an FDA approved dietary supplement and […]

Learn More >

Decoding nociceptor-DC dialogues.

Neuro-immune interactions link physiological and immune responses in host defense. Hanč et al. report that nociceptors attract dendritic cells (DCs) via the chemokine (C-C motif) ligand 2 (CCL2), initiate a “sentinel” […]

Learn More >

Potential novel therapeutic strategies for neuropathic pain.

To explore the potential therapeutic strategies of different types of neuropathic pain (NP) and to summarize the cutting-edge novel approaches for NP treatment based on the clinical trials registered on […]

Learn More >

Trace amine-associated receptor 1 regulation of Kv1.4 channels in trigeminal ganglion neurons contributes to nociceptive behaviors.

Trace amines, such as tyramine, are endogenous amino acid metabolites that have been hypothesized to promote headache. However, the underlying cellular and molecular mechanisms remain unknown.

Learn More >

The Clinical Application and Progress of Mirogabalin on Neuropathic Pain as a Novel Selective Gabapentinoids.

Neuropathic pain is a complex sort of pain that is detrimental to individuals’ health, both physically and mentally, but merely a small portion of them could witness pain alleviation. Mirogabalin, […]

Learn More >

Precision neuromodulation: Promises and challenges of spinal stimulation for multi-modal rehabilitation.

Spinal cord injury results in multiple, simultaneous sensorimotor deficits. These include, but are not limited to, full or partial paralysis of muscles below the lesion, muscle spasms, spasticity, and neuropathic […]

Learn More >

Treatment of plaque psoriasis with deucravacitinib (POETYK PSO-2 study): a plain language summary.

This is a summary of a paper published in a medical journal that describes the results of a study called POETYK PSO-2, which investigated a new treatment for plaque psoriasis. […]

Learn More >

Search