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Papers of the Week


Papers: 6 May 2023 - 12 May 2023

RESEARCH TYPE:
Commentary/Perspective


2023 May 09


Immunity


37163991


56


5

Decoding nociceptor-DC dialogues.

Authors

Crosson T, Talbot S

Abstract

Neuro-immune interactions link physiological and immune responses in host defense. Hanč et al. report that nociceptors attract dendritic cells (DCs) via the chemokine (C-C motif) ligand 2 (CCL2), initiate a “sentinel” DC program via the neuropeptide calcitonin gene-related peptide (CGRP), and enhance DC inflammatory responses through direct connections. These neuroimmune units integrate nociceptors’ rapid responsiveness with DCs’ immune coordination, functioning as an advanced warning system.