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Guidelines for the management of trigeminal neuralgia.

Guidelines for the diagnosis and treatment of patients with trigeminal neuralgia (TN) advocate for a multidisciplinary team approach to improve the care of patients with acute and chronic TN. Evidence-based […]

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Pharmacological Profiling of K Channel Modulators: An Outlook for New Treatment Opportunities for Migraine.

Migraine is a highly disabling pain disorder with huge socioeconomic and personal costs. It is genetically heterogenous leading to variability in response to current treatments and frequent lack of response. […]

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The top 100 most cited articles on Acupuncture in the last 20 years: a Bibliometric Analysis.

Acupuncture has gained increasing international attention in recent decades. The act of incorporating acupuncture treatment into the routine treatment of COVID-19 in China drove us to review the 100 most […]

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Population Pharmacokinetic Modeling of Zaltoprofen in Healthy Adults: Exploring the Dosage Regimen.

Zaltoprofen is a drug used for various pain and inflammatory diseases. Scientific and quantitative dosage regimen studies regarding its clinical application are scarce. This study aimed to discover effective covariates […]

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Prevalence and predictors of suicidality among adults initiating office-based buprenorphine.

Individuals who have substance use disorders may have an elevated risk of suicidality. This study sought to examine the prevalence of, and identify factors associated with, suicidality in adults with […]

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Reversal of Neuralgia Effect of Beta Carotene in Streptozotocin-Associated Diabetic Neuropathic Pain in Female Zebrafish via Matrix Metalloprotease-13 Inhibition.

Beta carotene is a natural anti-oxidant agent, and it inhibits the matrix metalloprotease (MMP) activity. Diabetic neuropathic pain (DNP) is produced by cellular oxidative stress. The role of the beta […]

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Identification and validation of biomarkers related to Th1 cell infiltration in neuropathic pain.

Neuropathic pain (NP) is a widespread chronic pain with a prevalence of 6.9-10% in the general population, severely affecting patients’ physical and mental health. Accumulating evidence indicated that the immune […]

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Migraine with and without aura in relation to the menstrual cycle and other hormonal milestones: A prospective cohort study.

Previous studies showed that the perimenstrual window is associated with an increased susceptibility to migraine attacks without aura, but had conflicting results regarding attacks with aura.

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The glycine receptor alpha 3 subunit mRNA expression shows sex-dependent differences in the adult mouse brain.

The glycinergic system plays an important inhibitory role in the mouse central nervous system, where glycine controls the excitability of spinal itch- and pain-mediating neurons. Impairments of the glycine receptors […]

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QuickStats: Percentage* of Adults Aged ≥18 Years Who Have Been Bothered a Lot by Headache or Migraine in the Past 3 Months, by Sex and Age Group – National Health Interview Survey, 2021.

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