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Percutaneous nephrolithotomy (PCNL) is a common endourological procedure for patients with large kidney stones, but the management of postoperative pain is still a major challenge. The aim of this clinical […]
Learn More >We investigated the efficacy of inhibiting persistent Na+ currents (INaP) in acute rodent models of migraine with aura. Cortical spreading depression (SD) is a slow wave of neuronal and glial […]
Learn More >Dorsal root ganglia (DRG) neurons have been well described for their role in driving both acute and chronic pain. Although nerve injury is known to cause transcriptional dysregulation, how this […]
Learn More >Parkinson disease (PD) affects up to 2% of the general population older than 65 years and is a major cause of functional loss. Chronic pain is a common nonmotor symptom […]
Learn More >Tissue-specific inflammatory diseases are regulated by several mechanisms. The gateway reflex and IL-6 amplifier are two mechanisms involved in diseases that depend on the inflammatory cytokine IL-6. The gateway reflex […]
Learn More >Juvenile idiopathic arthritis (JIA) is a chronic rheumatic disease causing joint inflammation and pain. Previous studies have indicated affected mental health and increased risk of psychiatric conditions among patients with […]
Learn More >Ingesting some foods can trigger headache attacks in migraine patients. Diet-sourced citrulline activates the L-arginine-nitric oxide pathway, acting on the pathophysiology of migraine.
Learn More >Advanced neuroimaging techniques have extensively contributed to elucidate the complex mechanisms underpinning the pathophysiology of migraine, a neurovascular disorder characterized by episodes of headache associated with a constellation of non-pain […]
Learn More >Janus kinase (JAK) inhibitors, including upadacitinib, have been recently approved for the treatment of moderate-severe atopic dermatitis (AD) and real-world data on upadacitinib effectiveness and safety are limited. This interim […]
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