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Translational

Home / Publications / Pain Research Forum / Papers of the Week / Translational
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Gendered meanings and mechanisms of intimacy for people living with chronic pain.

Cisheteronormative assumptions about women as able-bodied caregivers responsible for men’s sexual pleasure compound the stigma associated with chronic pain because of an assumed inability to fulfil gender roles in intimate […]

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Profiling the Spectrum of Headache Disorders on 440 Breast Cancer Patients: Highlights on Clinical and Pathological Mechanisms.

Although widely studied, the association between migraines (M) and breast cancer (BC) risk remains evasive. In this prospective single-center study, 440 early or locally advanced BC patients were enrolled at […]

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Risk factors for the long-term incidence and progression of knee osteoarthritis in older adults: role of nonsurgical injury.

For one of the most chronic medical conditions, osteoarthritis, uncertainties remain on the impact of injury chronology, the role of repeat injury on the incidence/progression of this disease and the […]

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Catecholaminergic and Cholinergic Systems Mediate Beneficial Effect of Vortioxetine on Diabetes-Induced Neuropathic Pain.

The therapeutic potential of vortioxetine on mechanical hyperalgesia/allodynia was investigated in rats with streptozotocin-induced diabetes, and its possible mechanism of action was elucidated in this study. The obtained findings demonstrated […]

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The temporal trend of placebo response in migraine prevention from 1990 to 2021: a systematic literature review and meta-analysis with regression.

Migraine affects 1.1 billion people globally and is the second leading cause of disability worldwide. In clinical trials, treatment efficacy is evaluated by comparing the differential responses in the treatment […]

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The Be-Home Kids Program: An Integrated Approach for Delivering Behavioral Therapies to Adolescents with Episodic and Chronic Migraine.

Migraine disorders are common in populations of children and adolescents. There are different pharmacological treatments for migraine in young patients, but none have specific indications, and doubts about their efficacy […]

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Influence of Cannabinoid Treatment on Trajectories of Patient-Related Outcomes in Chronic Pain: Pain Intensity, Emotional Distress, Tolerability and Physical Disability.

The treatment of chronic pain with cannabinoids is becoming more widespread and popular among patients. However, studies show that only a few patients experience any benefit from this treatment. It […]

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COMT Val158Met Affects the Analgesic Response to Acupuncture Among Cancer Survivors with Chronic Pain.

Catechol-O-methyltransferase (COMT) is the major enzyme involved in the catabolism of dopamine, a neurotransmitter in the brain’s reward system. The common COMT polymorphism Val158Met (rs4680 G>A) modulates pain response to […]

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Population-Based Characterization of Menstrual Migraine and Proposed Diagnostic Criteria.

There is a need for better recognition and more extensive research into menstrual migraine (MM) in the general population, and a revision of the diagnostic criteria for MM is warranted […]

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Chronic Pain, Analgesics, and Cognitive Status: A Comprehensive Mendelian Randomization Study.

Observational studies have suggested an intricate relationship among chronic pain (CP), use of analgesics, and cognitive status, but it remains unclear whether these associations are of a causal nature.

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