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Reduced cardiovagal baroreflex sensitivity is associated with postural orthostatic tachycardia syndrome (POTS) and pain chronification in patients with headache.

Non-cephalgic symptoms including orthostatic intolerance, fatigue, and cognitive impairment, are common in patients with chronic headache disorders and may result from alterations in the autonomic nervous system. However, little is […]

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Autologous Fat Grafting is not Superior to Placebo as Treatment of Postherpetic Neuralgia A Double-Blinded Randomized Clinical Trial.

Postherpetic neuralgia (PHN) is a chronic pain syndrome occurring after a herpes zoster (HZ) outbreak, also known as shingles. Treatment is complex, and no effective treatment exists today. Autologous fat […]

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A preoperative predictive model for stage IV endometriosis.

This was a retrospective study that evaluated a total of 280 patients who underwent surgery for complete removal of endometriosis to develop and validate the predictive model for stage IV […]

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Investigating Vitamin D Receptor Genetic Markers in a Cluster Headache Meta-Analysis.

Patients diagnosed with the primary headache disorder known as cluster headache (CH) commonly report that their headache attacks occur in patterns of both circadian and seasonal rhythmicity. Vitamin D is […]

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CAPER: Patient Preferences to Inform Non-Surgical Treatment of Chronic Low Back Pain (cLBP): A Discrete Choice Experiment.

We developed and used a discrete-choice measure to study patient preferences of risks and benefits of non-surgical treatments making cLBP treatment selections.

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Long-term consistency of clinical sensory testing measures for pain assessment.

Understanding the stability of quantitative sensory tests (QSTs) over time is important to aid clinicians in selecting a battery of tests for assessing and monitoring patients. This study evaluated the […]

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Cannabinoid Therapy: Attitudes and Experiences of People With Chronic Pain.

Clinical trials of cannabinoids for chronic pain have mixed and often inconclusive results. In contrast, many prospective observational studies show analgesic effects of cannabinoids. This survey study aimed to examine […]

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Higher self-perceived stress reactivity is associated with increased chronic pain risk.

Experiencing stress can contribute to unfavorable pain experiences, but outcomes vary across individuals. Evidence suggests that a person’s specific reactivity to stressful events may influence pain responses. Previous studies measuring […]

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A diagnostic support system based on pain drawings: binary and k-disease classification of EDS, GBS, FSHD, PROMM, and a control group with Pain2D.

The diagnosis of rare diseases (RDs) is often challenging due to their rarity, variability and the high number of individual RDs, resulting in a delay in diagnosis with adverse effects […]

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The Problem of Pain in the United States: A Population-Based Characterization of Biopsychosocial Correlates of High Impact Chronic Pain using the National Health Interview Survey.

Over 20 million adults in the United States live with High Impact Chronic Pain (HICP), or chronic pain that limits life or work activities for ≥3 months. It is critically […]

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