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Papers: 30 May 2020 - 5 Jun 2020
Animal Studies
PAIN TYPE:
Migraine/Headache
2020 Jun 02
Cephalalgia
Cortical spreading depression is thought to be the underlying mechanism of migraine aura. In 2006, three relatives having the point mutation E700K in exon 15 were diagnosed with familial hemiplegic migraine 2 characterized by complicated forms of aura. Here, we generated a transgenic mouse model having the human E700K mutation in the orthologous gene.