PRF News

The use of gold and gold-containing compounds in medicine can be traced back thousands of years in certain cultures. Gold salts have previously been shown to reduce pain, swelling, and […]

How many potential analgesic drug targets identified in animal research have failed to reach clinical use? It’s an answer that’s hard to estimate, but the problem of mistranslation of drug […]

Editor’s note: Stephen McMahon, PhD FMedSci (1954-2021), was a world-class researcher, lecturer, and inspiration to many. “Mac” worked relentlessly, and his last electrophysiology paper, presented within this news article, was […]

In the last few weeks, several news outlets like The New York Times and The Guardian have published provocative stories warning their readers that taking analgesics, like ibuprofen, can lead […]

Activity in the anterior cingulate cortex (ACC), a region of the medial prefrontal cortex (mPFC), has been reported to be involved in pain processing both in human and animal studies […]

Clinicians have observed the coexistence of chronic pain and depression for many years, and the two can often respond similarly to drug treatments. As in pain research, many papers have […]

Chronic pain, typically defined as pain lasting more than three months, is a public health issue that impacts the lives of millions of people across the world. It is a […]

In the classically aloof terminology of his time, 17th-century German physician Samuel Hafenreffer described pruritis, or itch, as an “unpleasant sensation that elicits the desire or reflex to scratch.” This […]

Spontaneous pain is notoriously difficult to treat. It can manifest in waves, seemingly at random, and is one of the most disruptive aspects of neuropathic pain conditions. In part, the […]