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When pain researchers think about ion channels and mechanical pain, which specific channels first come to mind? PIEZO2 may sit near the top of the list for many investigators, perhaps […]
Which cells are responsible for painful cold sensing in teeth – the sensation that can accompany eating ice cream, drinking iced tea, or having an infected tooth? And which signaling […]
Nociceptive sensory neurons innervate all the tissues of the body. Pain researchers have identified hundreds of receptors in such neurons over the past several decades, and these receptors are specialized […]
When it comes to chronic nerve injury pain, pro-inflammatory immune cells – microglia, in particular – receive the lion's share of attention. But new work shows that a specific population […]
How common is the transition from acute to chronic low back pain (LBP)? And what are the risk factors behind it? It's been difficult to answer these questions, in part […]
Painful diabetic neuropathy remains a stubborn problem in many patients. While alterations in endogenous opioid signaling in the central nervous system (CNS) have been associated with this condition, both in […]
About 14 million Americans live with knee osteoarthritis (KOA), a disease of the joint in in which knee cartilage breaks down over time. This chronic condition is associated with a […]
When it comes to venomous snakes, usually we think of these creatures as using venom to kill and eat their prey. However, a new study suggests that in one group […]
An objective biomarker of pain – it’s what many consider the Holy Grail of pain research. In recent years, brain activity signatures from neuroimaging studies have received a great deal […]
People who have pain are faced with the challenge of finding a way to express what is a subjective and multidimensional experience, usually by choosing a number on a pain […]