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Papers of the Week

Papers: 1 Jun 2024 - 7 Jun 2024

2024 May 30

Biochim Biophys Acta Mol Cell Res


Wnt/β-catenin signaling inhibits oxidative stress-induced ferroptosis to improve interstitial cystitis/bladder pain syndrome by reducing NF-κB.


Fang W, Song X, Li H, Meng F, Lv T, Huang J, Ji X, Lv J, Cai Z, Wang Z


Interstitial cystitis/bladder pain syndrome (IC/BPS) is a bladder syndrome of unknown etiology. Reactive oxygen species (ROS) plays a major role in ferroptosis and bladder dysfunction of IC/BPS, while the role of ferroptosis in IC/BPS progression is still unclear. This study aims to investigate the role and mechanism of ROS-induced ferroptosis in IC/BPS using cell and rat model.