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Papers of the Week

Papers: 25 May 2024 - 31 May 2024

2024 May 29

Bioelectron Med




TRPV1 nociceptors are required to optimize antigen-specific primary antibody responses to novel antigens.


Tynan A, Tsaava T, Gunasekaran M, Bravo Iñiguez CE, Brines M, Chavan SS, Tracey KJ


Key to the advancement of the field of bioelectronic medicine is the identification of novel pathways of neural regulation of immune function. Sensory neurons (termed nociceptors) recognize harmful stimuli and initiate a protective response by eliciting pain and defensive behavior. Nociceptors also interact with immune cells to regulate host defense and inflammatory responses. However, it is still unclear whether nociceptors participate in regulating primary IgG antibody responses to novel antigens.