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Papers of the Week

Papers: 23 Dec 2023 - 29 Dec 2023

2023 Nov 30

Pharmaceuticals (Basel)




The Anti-Nociceptive Effects of Nicotine in Humans: A Systematic Review and Meta-Analysis.


Luo Y, Yang Y, Schneider C, Balle T


Pain can have a serious impact on a patient’s physical, mental, and social health, often causing their quality of life to decline. Various nicotine dosage forms, such as nicotine patches and nasal spray, have been developed and used as analgesics in clinical settings. However, there is controversy over the anti-nociceptive effects of nicotine among different clinical trials. The purpose of this meta-analysis is to quantify the analgesic effect of nicotine patches, nicotine nasal spray, and tobacco smoking on pain in humans.