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Papers of the Week
Sustained nerve growth factor-induced C-nociceptor sensitization to electrical sinusoidal stimulation in humans.
Authors
Solinski HJ, Schmelz M, Rukwied RAbstract
Injection of recombinant human nerve growth factor (rhNGF) evokes acute heat and prolonged “polymodal” (mechanosensitive [CM]) and “silent” (mechanosensitive [CMi]) C-nociceptor sensitization. Both nociceptor classes can be activated differentially using slowly depolarizing electrical sinusoidal stimuli.