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Papers of the Week

Papers: 18 Nov 2023 - 24 Nov 2023

2023 Nov 08

Clin Exp Rheumatol


Soluble low affinity nerve growth factor receptor (sLNGFR) may regulate pain in knee osteoarthritis.


Altaie A, Campbell TM, Owston H, Jones E, Doyle R, Feibel RJ, Pandit H, Westbrook S, McGonagle D


Nerve growth factor β (β-NGF) is a protein which is important to the development of neurons particularly those involved in the transmission of pain and is central to the experience of pain in osteoarthritis (OA). Direct NGF antagonism has been shown to reduce OA pain but is associated with rapidly progressive OA. The aim of the study is to investigate the ability of soluble neurotrophin receptors in the NGF pathway to modulate pain in OA.