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Papers of the Week


Papers: 4 Mar 2023 - 10 Mar 2023

RESEARCH TYPE:
Translational


Human Studies, In Silico Studies, Neurobiology

PAIN TYPE:
Musculoskeletal Pain


2023 Feb 20


Comput Methods Programs Biomed


36868164


232

Relationship between physical activity and central sensitization in chronic low back pain: Insights from machine learning.

Authors

Zheng X, Reneman MF, Preuper RHS, Otten E, Lamoth CJ

Abstract

Chronic low back pain (CLBP) is a leading cause of disability. The management guidelines for the management of CLBP often recommend optimizing physical activity (PA). Among a subsample of patients with CLBP, central sensitization (CS) is present. However, knowledge about the association between PA intensity patterns, CLBP, and CS is limited. The objective PA computed by conventional approaches (e.g. cut-points) may not be sensitive enough to explore this association. This study aimed to investigate PA intensity patterns in patients with CLBP and low or high CS (CLBP-, CLBP+, respectively) by using advanced unsupervised machine learning approach, Hidden semi-Markov model (HSMM).