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Papers of the Week

Papers: 18 Nov 2023 - 24 Nov 2023

2023 Nov 20

Eur J Pain


Placebo analgesia in physical and psychological interventions: Systematic review and meta-analysis of three-armed trials.


Hohenschurz-Schmidt D, Phalip J, Chan J, Gauhe G, Soliman N, Vollert J, Lunde SJ, Vase L


The magnitude of placebo effects from physical and psychological ‘sham’ is unknown but could impact efficacy trials and treatment understanding. To quantify placebo effects, this systematic review of three-armed randomised controlled trials (RCTs) of physical and psychological interventions for pain compared outcomes in ‘sham’ control intervention and non-exposure arms.