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Papers of the Week

Papers: 15 Jun 2024 - 21 Jun 2024

2024 Jun 19

J Headache Pain




Occurrence of new or more severe headaches following COVID-19 is associated with markers of microglial activation and peripheral sensitization: results from a prospective cohort study.


Ruhnau J, Blücher M, Bahlmann S, Zieme A, Vogelgesang A, Steinmetz A, Fleischmann R


New onset or worsening of a headache disorder substantially contributes to the disease burden of post-COVID-19. Its management poses a suitable means to enhance patients’ participation in professional, social, and personal activities. Unfortunately, the pathophysiology of post-COVID-19 headaches is poorly understood. This study aims to investigate the role of (neuro-) inflammatory mechanisms in order to guide the development of anti-inflammatory treatment strategies.