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Papers of the Week

Papers: 18 Feb 2023 - 24 Feb 2023

Basic Science, Psychology

Animal Studies, Pharmacology/Drug Development

2023 Feb 21

Life Sci


Nicorandil reduces morphine withdrawal symptoms, potentiates morphine antinociception, and ameliorates liver fibrosis in rats.


Bedair AF, Wahid A, El-Mezayen NS, Afify EA


Chronic liver disease (CLD) is a serious medical condition affecting patients globally and pain management poses a unique challenge. ATP-sensitive potassium channels (K) are expressed in nociceptive neurons and hepatic cells. We tested the hypothesis whether morphine and nicorandil, K channel opener, alone and in combination possess hepatoprotective, antinociceptive effect and alter morphine physical dependence.