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Nicorandil antiallodynic activity in a model of neuropathic pain is associated with the activation of ATP-dependent potassium channels and opioidergic pathways, and reduced production of cytokines and neutrophils recruitment in paw, sciatic nerve, and dorsal root ganglia.
Authors
Braga AV, Morais MÍ, Delfino DGS, Costa SOAM, Barbosa BCM, Rodrigues FF, Melo ISF, Matos RC, Castro BFM, Cunha Júnior AS, Braga TC, de Fátima Â, Coelho MM, Machado RRAbstract
Recently, we demonstrated that nicorandil inhibits mechanical allodynia induced by paclitaxel. In the present study, we evaluated the effect induced by nicorandil in a model of neuropathic pain induced by chronic constriction injury (CCI) in mice. We also investigated putative mechanisms underlying such an effect.