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Papers of the Week


Papers: 2 Sep 2023 - 8 Sep 2023

RESEARCH TYPE:
Basic Science


Human Studies, Molecular/Cellular, Pharmacology/Drug Development

PAIN TYPE:
Psychological/Comorbidities


2023 Sep 01


Anesthesiology


37656771

Neurocognitive effect of biased µ-opioid receptor agonist oliceridine, a utility function analysis and comparison with morphine.

Authors

Moss L, Hijma H, Demitrack M, Kim J, Groeneveld GJ, van Velzen M, Niesters M, Olofsen E, Dahan A

Abstract

Oliceridine (Olinvyk®) is a μ-opioid receptor agonist that in contrast to conventional opioids preferentially engages the G-protein-coupled signaling pathway. We determined the utility function of oliceridine versus morphine based on neurocognitive tests and cold pressor test.