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Papers of the Week


Papers: 30 Mar 2024 - 5 April 2024


2024


ADMET DMPK


38560716


12


1

Nanomaterials as catalysts for the sensitive and selective determination of diclofenac.

Authors

Dodevska T, Shterev I

Abstract

Diclofenac (DCF) is a non-steroidal anti-inflammatory drug possessing analgesic and antipyretic properties. It is used for the treatment of rheumatoid arthritis pain, osteoarthritis, and acute muscle pain conditions and can be administrated orally, topically or intravenously. Because of its widespread use, hydrophilicity, stability and poor degradation (bioaccumulation in the food chain), DCF is an emerging chemical contaminant that can cause adverse effects in the ecosystems. Taking into account the consumption of DCF in pharmaceutical formulations and its negative impact on the environment, the development of new sensitive, selective, cheap, fast, and online capable analytical devices is needed for on-site applications.