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Papers of the Week

Papers: 30 Dec 2023 - 5 Jan 2024

2024 Jan 05

J Headache Pain




Microglia TREM1-mediated neuroinflammation contributes to central sensitization via the NF-κB pathway in a chronic migraine model.


Sun S, Fan Z, Liu X, Wang L, Ge Z


Neuroinflammation, mediated by the activation of microglia, contributes to central sensitization, which is associated with the development of chronic migraine (CM). TREM1 receptors amplify the inflammatory response. However, their relationship to CM is unclear. Thus, this study endeavoured to elucidate the exact role of TREM1 in CM.