Browse by Audience
Skip to content
Papers of the Week
Mendelian randomization highlights sleep disturbances mediated the effect of depression on chronic pain.
Authors
Zhu Y, Bi Y, Zhu TAbstract
Depression and chronic pain are significant contributors to the global burden of disease. Previous research has revealed complex relationships between these two conditions, which may be influenced by sleep quality. However, observational studies have limitations, including confounding factors and reverse causation. This study aims to explore the mediating effects of sleep on the relationship between depression and chronic pain using Mendelian randomization (MR).