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Papers of the Week

Papers: 11 Nov 2023 - 17 Nov 2023

2023 Nov 10

CNS Neurosci Ther


Involvement of microglial P2X7 receptor in pain modulation.


Zhang J, Gao L, Zhang Y, Wang H, Sun S, Wu LA


Pain is a rapid response mechanism that compels organisms to retreat from the harmful stimuli and triggers a repair response. Nonetheless, when pain persists for extended periods, it can lead to adverse changes into in the individual’s brain, negatively impacting their emotional state and overall quality of life. Microglia, the resident immune cells in the central nervous system (CNS), play a pivotal role in regulating a variety of pain-related disorders. Specifically, recent studies have shed light on the central role that microglial purinergic ligand-gated ion channel 7 receptor (P2X7R) plays in regulating pain. In this respect, the P2X7R on microglial membranes represents a potential therapeutic target.