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Papers of the Week

Papers: 18 Nov 2023 - 24 Nov 2023

2023 Nov 18

Cell Signal


Inhibition of spinal Rac1 attenuates chronic inflammatory pain by regulating the activation of astrocytes.


Wan Y, Zhou J, Zhang P, Lin X, Li H


Spinal astrocyte-mediated neuroinflammation is an important mechanism for the maintenance of chronic inflammatory pain. Previous studies have investigated that Ras-related C3 botulinum toxin substrate 1 (Rac1) is closely related to astrocyte activation after central nervous system injury. However, the role of Rac1 in astrocyte activation in chronic inflammatory pain has not been reported.