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Papers of the Week

Papers: 22 Jul 2023 - 28 Jul 2023

Basic Science

Animal Studies, Neurobiology, Pharmacology/Drug Development

Arthritis, Inflammation/Inflammatory

2023 Jul 23

Br J Pharmacol


Inhibition of Brd4 alleviates osteoarthritis pain via suppression of neuroinflammation and activation of Nrf2-mediated antioxidant signaling.


Sun J, Wang XH, Song FH, Li DY, Gao SJ, Zhang LQ, Wu JY, Liu DQ, Wang LW, Zhou YQ, Mei W


Osteoarthritis (OA) pain remains a major clinical problem. It is urgent to identify novel therapeutic approaches for OA pain states. Bromodomain and extraterminal (BET) protein inhibitors have robust anti-inflammatory effects in several pain models. However, the underlying mechanisms of these inhibitors in OA pain are yet to be determined. We, therefore, investigate the efficacy of BET inhibition on pain-related behaviors in a rat model of monosodium iodoacetate (MIA)-induced osteoarthritis pain and their underlying mechanisms.