Browse by Audience
Skip to content
Papers of the Week
Identification of CD64 as a marker for the destructive potential of synovitis in osteoarthritis.
Authors
Teunissen van Manen IJ, van Kooten NJT, Di Ceglie I, Theeuwes WF, Jimenez-Royo P, Cleveland M, van Lent PLEM, van der Kraan PM, Blom AB, van den Bosch MHJAbstract
Osteoarthritis (OA) is characterised by cartilage degeneration and persistent pain. The majority of OA patients present with synovitis, which is associated with increased cartilage damage. Activated synovial macrophages are key contributors to joint destruction. Therefore, a marker that reflects the activation of these cells could be a valuable tool to characterise the destructive potential of synovitis and benefit monitoring of OA. Here, we aimed to investigate the use of CD64 (FcγRI) as a marker to characterise the damaging potential of synovitis in OA.