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Papers of the Week

Papers: 5 Aug 2023 - 11 Aug 2023

Basic Science, Integrative/Complementary

Animal Studies, Molecular/Cellular, Neurobiology, Neuromodulation

Inflammation/Inflammatory, Orofacial/Head Pain

2023 Aug 07

Brain Behav


Electroacupuncture ameliorates pain in cervical spondylotic radiculopathy rat by inhibiting the CaMKII/CREB/BDNF signaling pathway and regulating spinal synaptic plasticity.


Su H, Chen H, Zhang X, Su S, Li J, Guo Y, Wang Q, Xie C, Yang P


Central sensitization is one of the important mechanisms underlying neuropathic and radicular pain due to cervical spondylotic radiculopathy (CSR). Recent studies have shown that the calmodulin-dependent protein kinase II (CaMKII)/cAMP-response element binding protein (CREB)/brain-derived neurotrophic factor (BDNF) signaling pathway mediates central sensitization through its involvement in spinal cord synaptic plasticity. Our group has previously found that electroacupuncture (EA) has a good analgesic effect on CSR. However, the central analgesic mechanism of EA for CSR is not yet clear.