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Papers of the Week
Effects of Etanercept on Experimental Osteoarthritis in Rats: Role of Histone Deacetylases.
Authors
Wen ZH, Tang CC, Lin YY, Yao ZK, Hsieh SP, Gar-Hwa-Lai , Chen WF, Jean YHAbstract
Mounting evidence suggests that histone deacetylases (HDAC) inhibitors reduce cartilage destruction in animal models of osteoarthritis (OA). Tumor necrosis factor (TNF)-α-blocking treatment for OA may provide effective joint protection by slowing joint damage. To investigate the effects of intraperitoneal administration of etanercept (a TNF-α inhibitor) on OA development in rats and changes in the nociceptive behavior of rats and expression of HDACs, RUNX2, and MMP13 in cartilage.